Relationship of Cell Compositions in Allografts with Outcomes after Haploidentical Transplantation for Acquired Severe Aplastic Anemia
نویسندگان
چکیده
منابع مشابه
Haploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia
Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT...
متن کاملhematopoietic stem cell transplantation in patients with severe acquired aplastic anemia: iranian experience
introduction: severe acquired aplastic anemia (saa) is a rare disease and matched related hematopoietic stem cell transplantation (hsct) is the treatment of choice especially in pediatric patients. immunosuppressive therapy is the alternative treatment in patients who do not have a donor. we retrospectively analyzed patients who received allogeneic hsct at our institution. methods: between 1991...
متن کاملClinical applications of haploidentical hematopoietic stem cell transplantation in severe aplastic anemia.
OBJECTIVE The purpose of this study was to investigate the efficacy and safety of haploidentical allogeneic hemopoietic stem cell transplantation (allo-HSCT) in severe aplastic anemia (SAA) and prophylaxis of complications involved. PATIENTS AND METHODS 8 patients with clinically diagnosed SAA (5 cases of SAA-I and 3 cases of SAA-II) were recruited, with the parents as the donors of hemopoiet...
متن کاملUpfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant
BACKGROUND Haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) is an alternative treatment method for severe aplastic anemia (SAA) patients lacking suitable identical donors and those who are refractory to immunosuppressive therapy (IST). The current study evaluated the feasibility of upfront haploidentical HSCT in SAA patients. METHODS We conducted a multicenter study b...
متن کاملEffect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia.
Outcome after unrelated donor bone marrow (BM) transplantation for severe aplastic anemia (SAA) has improved, with survival rates now approximately 75%. Increasing use of peripheral blood stem and progenitor cells (PBPCs) instead of BM as a graft source prompted us to compare outcomes of PBPC and BM transplantation for SAA. We studied 296 patients receiving either BM (n = 225) or PBPC (n = 71) ...
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ژورنال
عنوان ژورنال: Chinese Medical Journal
سال: 2018
ISSN: 0366-6999
DOI: 10.4103/0366-6999.240810